Faculty: Ana Cristina Andreazza, PhD

Ana Cristina Andreazza, PhDAna Cristina Andreazza, PhD
Associate Professor
Department of Pharmacology & Toxicology   
Department of Psychiatry
Centre for Addiction and Mental Health 

Dr. Andreazza received a PhD in Biochemistry from the Federal University of Rio Grande do Sul, RS, Brazil. Currently, Dr. Andreazza is Associate Professor, Departments of Pharmacology & Toxicology and Psychiatry, University of Toronto and holds a cross-appointment as Independent Scientist, at the Centre for Addiction and Mental Health, University of Toronto. Dr. Andreazza has published several research articles in high-ranking journals (see bibliography). She is the recipient of several prestigious research awards and has received funding from the Brain and Behavior Foundation (NARSAD), the Canadian Institutes for Health Research, the Ontario Mental Health Foundation and the Ontario Ministry of Research and Innovation. Her research focuses on the understanding of the role of redox modulations and mitochondrial dysfunction in mental illness, especially in mood disorders. Her research, in collaboration with other laboratories, has produced some of the most convincing insights, as yet, into the mechanisms that underlie mood disorders. Dr. Andreazza is currently exploring the possible effects of redox modulations on molecular pathways leading to synaptic alterations, particularly those, which might provide potential avenues for therapy. She is also investigating the role of redox dysregulation (i.e. mitochondrial dysfunction and lipid oxidation) and inflammation in signaling white matter changes in mood disorder.

Select Publications

1.    Nascimento C, Kim HK, Young LT, Mendonça KM, Grinberg LT, Lafer B, Andreazza AC. Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J Neural Transm (Vienna). 2015 Jun;122(6):741-6.
2.    Kim HK, Chen W, Andreazza AC. The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder. Neural Plast. 2015;2015:408136
3.    Kim HK, Andreazza AC, Elmi N, Chen W, Young LT. Nod-like receptor pyrin containing 3 (NLRP3) in the post-mortem frontal cortex from patients with bipolar disorder: A potential mediator between mitochondria and immune-activation. J Psychiatr Res. 2015 Oct 26;72:43-50
4.    Versace A*, Andreazza AC*, Young LT; Fournier JC, Almeida JRC, Stiffler RS, Lockovich J; Aslam HA, Pollock MH, Park H; Nimgaonkar VL, Kupfer DJ, Phillips ML. Elevated serum measures of lipid oxidation and abnormal prefrontal white matter in euthymic bipolar adults: toward peripheral biomarkers of bipolar disorder. Molecular Psychiatry. 2014 Feb;19(2):200-8.  Contributed equally for the first authorship position of this manuscript 
5.    Scola G, Kim HK, Young LT, Salvador M, Andreazza AC. Lithium reduces the effects of rotenone-induced complex I dysfunction on DNA methylation and hydroxymethylation in rat cortical primary neurons. Psychopharmacology (Berl). 2014;231(21):4189
6.    Scola G, Kim HK, Young LT, Andreazza AC. A Fresh Look at Complex I in Microarray Data: Clues to Understanding Disease-Specific Mitochondrial Alterations in Bipolar Disorder. Biological Psychiatry. 2013, 73(2) e4To-e5.

Department of Pharmacology & Toxicology
MSB 4204
1 King's College Circle
Toronto, Ontario
M5S 1A8
Phone: 416-978-6042
FAX: 416-978-6395
Email: ana.andreazza@utoronto.ca

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