Faculty: Cindy Woodland, PhD
Associate Professor, Teaching Stream
Director, Collaborative Program in Biomedical Toxicology
Director, Applied Clinical Pharmacology Program
General Research Areas: Toxicology; Drug Metabolism; Clinical Pharmacology; Drug Biotransformation and Transport
NOT TAKING GRADUATE STUDENTS
My research focus is drug-induced toxicity, particularly that involving drug metabolizing enzymes and/or drug transporters. I am interested in the ontogeny, expression, and function of P-glycoprotein and other drug transporters and their involvement in drug-drug interactions. I also study the mechanisms of bioactivation and detoxification of potentially nephrotoxic species. My clinical research interests include drug-induced renal toxicity and the safety of drugs in pregnancy.
Please note: My current administrative duties prevent me from doing any active research. Therefore, I am not accepting any graduate or summer students.
Woodland C, Huang TT, Gryz E, Fawcett JP, Bendayan R. Expression, Activity and Regulation of CYP3A in Human and Rodent Brain. Drug Metab Rev. 2008; 40(1):149-68.
Chen N, Aleksa K, Woodland C, Rieder M, Koren G. N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats. Br J Pharmacol. 2008 Feb 18; [Epub ahead of print].
Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. Can J Clin Pharmacol. 2007; 14(2):e246-50.
Chen N, Aleksa K, Woodland C, Rieder M, Koren G. The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. Transl Res.2007; 150(1):51-7.
Sarkar M, Woodland C, Koren G, Einarson AR. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth. 2006; 6:18.
Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Ontogeny of drug elimination by the human kidney. Pediatr Nephrol. 2006; 21(2):160-8.
Pinto N, Halachmi N, Verjee Z, Woodland C, Klein J, Koren G. Ontogeny of renal P-glycoprotein expression in mice: correlation with digoxin renal clearance. Pediatr Res.2005; 58(6):1284-9.
University of Toronto
Department of Pharmacology and Toxicology
Room 4209, Medical Sciences Building
1 King's College Circle
Phone:  978-3102
FAX:  978-6395