Faculty: Cindy Woodland, PhD

Cindy Woodland, PhDCindy Woodland, PhD

Associate Professor, Teaching Stream
Director, Collaborative Program in Biomedical Toxicology
Director, Applied Clinical Pharmacology Program

General Research Areas: Toxicology; Drug Metabolism; Clinical Pharmacology; Drug Biotransformation and Transport


My research focus is drug-induced toxicity, particularly that involving drug metabolizing enzymes and/or drug transporters. I am interested in the ontogeny, expression, and function of P-glycoprotein and other drug transporters and their involvement in drug-drug interactions. I also study the mechanisms of bioactivation and detoxification of potentially nephrotoxic species. My clinical research interests include drug-induced renal toxicity and the safety of drugs in pregnancy.  

Please note: My current administrative duties prevent me from doing any active research. Therefore, I am not accepting any graduate or summer students.


Selected Publications: 

Woodland C, Huang TT, Gryz E, Fawcett JP, Bendayan R. Expression, Activity and Regulation of CYP3A in Human and Rodent Brain. Drug Metab Rev. 2008; 40(1):149-68. 

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats. Br J Pharmacol. 2008 Feb 18; [Epub ahead of print]. 

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Prevention of ifosfamide nephrotoxicity by N-acetylcysteine: clinical pharmacokinetic considerations. Can J Clin Pharmacol. 2007; 14(2):e246-50.

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. Transl Res.2007; 150(1):51-7.

Sarkar M, Woodland C, Koren G, Einarson AR. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth. 2006; 6:18. 

Chen N, Aleksa K, Woodland C, Rieder M, Koren G. Ontogeny of drug elimination by the human kidney. Pediatr Nephrol. 2006; 21(2):160-8. 

Pinto N, Halachmi N, Verjee Z, Woodland C, Klein J, Koren G. Ontogeny of renal P-glycoprotein expression in mice: correlation with digoxin renal clearance. Pediatr Res.2005; 58(6):1284-9.


Contact Address:

University of Toronto 
Department of Pharmacology and Toxicology
Room 4209, Medical Sciences Building 
1 King's College Circle 
Toronto, Ontario 
M5S 1A8 
Phone: [416] 978-3102 
FAX: [416] 978-6395
Email: cindy.woodland@utoronto.ca

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