Faculty: Hong-Shuo Sun, MD, MSc, PhD
General Research Areas: Cardiovascular/Neuropharmacology; Ion Channels; Ischemia/Stroke
Our research interest is in studying the role of ion channels in neuroprotection against cerebral ischemia and stroke, and identifying potential therapeutic targets for stroke. The experimental approaches used in our lab include in-vivo animal models of diseases in combination with genomic and proteomic analyses, advanced imaging, electrophysiology, and functional and behavioural assessments. These approaches will allow us to: 1) study the cellular and molecular mechanisms underlying ischemia and stroke; 2) to identify potential molecular targets that are responsible for the stress- and ischemia- induced cell injury; 3) to develop pharmacological strategies for cytoprotection against the cell injury. We also interest in channelopathy (ion channel diseases).
Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, MacDonald JF, Tymianski M. Suppression of Hippocampal TRPM7 Protein Prevents Delayed Neuronal Death in Brain Ischemia. Nature Neuroscience. 2009; 12(10): 1300-1307.
Sun HS, Doucette TA, Liu Y, Fang Y, Teves L, Aarts M, Ryan C, Bernard PB, Lau A, Forder JP, Salter MW, Wang YT, Tasker RA, Tymianski M. Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat. Stroke. 2008; 39(9): 2544-2553.
Wei WL, Sun HS, Olah ME, Sun X, Czerwinska E, Czerwinski W, Mori Y, Orser BA, Xiong ZG, Jackson MF, Tymianski M, MacDonald JF. TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci USA. 2007; 104(41): 16323-8.
Sun HS, Hui K, Lee D, Feng ZP. Zn sensitivity of high-voltage activated and low-voltage activated calcium channels. Biophys J. 2007; 93(4): 1175-1183.
Sun HS, Feng ZP, Miki T, Seino S, French RJ. Enhanced neuronal damage after ischemic insults in mice lacking the Kir6.2 -containing ATP-sensitive K+ channels. J Neurophysiol. 2006; 95(4): 2590-2601.
Division of Anatomy, Department of Surgery
Faculty of Medicine, University of Toronto
Rm. 1185 Medical Sciences Building
1 King's College Circle
Toronto, Ontario M5S 1A8
Phone: (416) 978-8848
Fax: (416) 978-3844