Faculty: Jane Mitchell, PhD

Jane Mitchell, PhDJane Mitchell, PhD
Associate Professor & Associate Chair
Department of Pharmacology and Toxicology

General Research Area: Signal Transduction/ Receptor Pharmacology
Regulation of G protein-Coupled Receptor Signaling Systems in Bone and Retina

Research in my laboratory focuses on several topics. CIHR-funded projects In the skeletal system  investigate the effects of glucocorticoids on bone and muscle. We utilize mouse models to determine the molecular mechanisms through which glucocorticoids inhibit bone growth and cause osteoporosis.  We also examine the effect of glucocorticoids on the skeletal system in mouse models of Duchenne muscular dystrophy.

Our NSERC-funded research projects investigate visual signalling systems using purified proteins to investigate the structural interactions between rhodopsin, G protein subunits, arrestin, receptor kinase and phospholipase C.

Selected Publications

Dela Cruz A, Mattocks M, Sugamori K, Grynpas M, Mitchell J. (2014) Reduced trabecular bone mass and strength in mice overexpressing G11 protein in cells of the osteoblast lineage. Bone. 2014 :211-22.

Barbuto R, Mitchell J. (2013) Regulation of the osterix (Osx, Sp7) promoter by osterix and its inhibition by parathyroid hormone. J Mol Endo 2013 Jun 18;51(1):99-108.

Mitchell J, Lai LP, Peralta F, Xu Y, Sugamori K. (2011) β2-Adrenergic Receptors Inhibit the Expression of Collagen Type II in Growth Plate Chondrocytes by Stimulating the AP-1 Factor Jun-B. Am J Physiol Endocrinol Metab. 300:E633-E639.

Hong SHH, Lu X, Names SM, Mitchell J. (2009) Regulation of osterix (Osx, Sp7)and the Osx promoter by parathyroid hormone in osteoblasts. J Mol Endo 43:197-207.

Tong D, Rozas N, Oakley T, Mitchell J, Colley N, McFall-Ngai M. (2009) Evidence for light perception in a bioluminescent organ. Proc Natl Acad Sci USA.106:9836-41. 

Contact:

University of Toronto 
Department of Pharmacology and Toxicology 
Room 4342, Medical Sciences Building 
1 King's College Circle 
Toronto, Ontario 
M5S 1A8
Phone: [416]978-0841 
FAX: [416]978-6395
Email: jane.mitchell@utoronto.ca

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