Faculty: Jeffrey H. Meyer, MD PhD FRCP(C)

Jeffrey H. Meyer, MD PhD FRCP(C)Jeffrey H. Meyer, MD PhD FRCP(C)
Associate Professor, Department of Psychiatry, Medical Sciences, Pharmacology
Canada Research Chair in Neurochemistry of Major Depressive Disorder
Head, Neurochemical Imaging in Mood Disorders, Toronto PET Centre, Centre for Addiction and Mental Health

General Research Area: Understanding Contributions of Monoamine Dysregulation to Mechanisms of Onset and Treatment Resistance in Major Depressive Disorder

Techniques include: positron emission tomography, human clinical trials, functional magnetic resonance brain imaging, cognitive testing, Western blot, enzyme assays, natural health product development.

Current research directions include:

  • Monoamine Dysregulation in Major Depressive Episodes with and without Comorbid Psychiatric Illness
  • Recurrence of Major Depressive Episodes
  • Seasonal Affective Disorder
  • Postpartum Depression
  • Antidepressant Occupancy
  • Antidepressant Effects Upon Pathophysiology and Dimensions of Illness
  • Prevention Strategies Against Onset of Major Depressive Episodes


Selected Publications:

Bacher I, Houle S, Xu C, Zawertailo L, Wilson AA, Selby P, George T, Sacher J, Miler L, Kish SJ, Soliman A, Rusjan P, Meyer JH. Rapid Rise in Monoamine Oxidase A Binding In Prefrontal and Anterior Cingulate Cortex During Acute Cigarette Withdrawal. Arch Gen Psych. (in press).

Sacher J, Wilson AA, Houle S, Hassan S, Rusjan P, Bloomfield P, Stewart D, Meyer JH. Elevated Brain Monoamine Oxidase A Binding In Human Early Postpartum. Arch Gen Psych. 2010; 67(5):468-74.

Meyer JH, Wilson AA, Sagrati S, Miler L, Rusjan P, Bloomfield PM, Clark M, Sacher J, Voineskos AN, Houle S. Brain Monoamine Oxidase A Binding in Major Depressive Disorder: Relationship to Selective Serotonin Reuptake Inhibitor Treatment, Recovery and Recurrence. Arch Gen Psych. 2009; 66(12): 1304-1312.

Praschak Rieder N, Willeit M, Wilson AA, Houle S, Meyer JH. Season, Sunlight and Serotonin Transporters in Living Human Brain. Arch Gen Psych 2008; 65(9): 1072-1078.

Voineskos AN, Wilson AA, Boovariwala A, Sagrati A, Houle A, Rusjan P, Sokolov S, Spencer EP, Ginovart N, Meyer JH. Serotonin Transporter Occupancy of High Dose Selective Serotonin Reuptake Inhibitors Measured With [11C]DASB Positron Emission Tomography Psychopharmacology 2007: 193(4): 539-545.

Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D, Garcia A, Young LT, Praschak-Rieder N, Wilson AA, Houle S. Elevated Brain Monoamine Oxidase-A: An Explanation for the Monoamine Imbalance of Major Depression. Arch Gen Psych 2006; 63(11): 1209-1216.

Meyer JH, McNeely H, Sagrati S, Boovariwala A, Martin K, Verhoeff NPLG, Wilson AA, Houle S. Striatal D2 Receptor Binding Potential and its Relationship to Motor Retardation in Major Depression. Am J Psychiat 2006; 163(9):1594-602.

Praschak-Rieder N, Wilson AA, Hussey DH, Carella A, Wei C, Ginovart N, Schwarz MJ, Zach J, Houle S, Meyer JH. Effects of Tryptophan Depletion Upon the Serotonin Transporter in Healthy Humans. Biol Psychiat 2005; 58(10):825-30.

Meyer JH, Houle S, Sagrati S, Carella A, Hussey D, Ginovart N, Goulding V, Kennedy JL, Wilson AA. The Serotonin Transporter and its Relationship to Dysfunctional Attitudes During Major Depressive Episodes. Arch Gen Psychiat 2004; 61(12): 1271-1279.

Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, Houle S. Serotonin Transporter Occupancy of Five Selective Serotonin Reuptake Inhibitors at Different Doses: An [11C] DASB Positron Emission Tomography Study. Am J Psychiat 2004; 161(5): 826-35.


Center for Addiction and Mental Health
250 College Street, 11th Floor
Toronto, ON
M5T 1R8
Telephone: 416-535-8501 X4007
Email: jeff.meyer@camhpet.ca

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