Faculty: Jeffrey H. Meyer, MD PhD FRCP(C)
Professor, Department of Psychiatry, Pharmacology & Toxicology
Canada Research Chair in Neurochemistry of Major Depressive Disorder
Head, Neurochemical Imaging in Mood Disorders, Toronto PET Centre, Centre for Addiction and Mental Health
General Research Area:
Dr. Meyer’s priorities are identifying mechanisms of treatment-resistant depression and prevention of major depressive episodes, through identifying and understanding modifiable biological markers related to onset, and persistence of major depressive episodes. His current targets of interest are neuroinflammatory markers of gliosis, mitochondrial markers (like monoamine oxidase A and monoamine oxidase B), and markers of synaptic density. He primarily applies neuroimaging, but also uses related markers in preclinical approaches, towards understanding mechanisms. He is also involved in early phase trials of novel therapeutics, phase 0 trials to target pathological markers of depression, the development of new natural health products and the creation of novel peripheral biomarkers of mood disorders.
Techniques include: positron emission tomography, biomarker development, MR spectroscopy, human clinical trials, cognitive testing, Western blot, enzyme assays, natural health product development.
Current research directions include:
- PET investigation of neurochemical abnormalities in Major Depressive Episodes Comorbid Psychiatric Illnesses, and High Risk States for Major Depressive Episodes (including neuroinflammation and monoamine oxidase)
- Recurrence of Major Depressive Episodes
- Postpartum Depression
- Traumatic Brain Injury
- Antidepressant Occupancy
- Antidepressant Effects on Pathophysiology and Dimensions of Illness
- Prevention Strategies Against Onset of Major Depressive Episodes
Moriguchi S, Wilson AA, Miler L, Rusjan PM, Vasdev N, Kish SJ, Rajkowska G, Wang J, Bagby M, Mizrahi R, Varughese B, Houle S, Meyer JH. Monoamine Oxidase B Total Distribution Volume in the Prefrontal Cortex of Major Depressive Disorder: An [11C]SL25.1188 Positron Emission Tomography Study. JAMA Psychiatry 2019 (epub)
Setiawan E, Attwells S, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Xu X,Sharma S, Kish S, Houle S, Meyer JH. Translocator Protein Distribution Volume As A Marker of Neuroprogression in Major Depressive Disorder Lancet Psychiatry 2018 Apr;5(4):339-347.
Attwells S, Setiawan E, Wilson AA, Rusjan PM, Mizrahi R, Miler L, Xu X, Richter MA, Kahn A, Kish SJ, Houle S, Ravindran L, Meyer JH. Inflammation in the neurocircuitry of obsessive compulsive disorder. JAMA Psychiatry 2017; 74(8):833-840.
Dowlati Y, Ravindran AV, Segal ZV, Stewart DE, Steiner M, Meyer JH. Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood. PNAS Central 2017 Mar; 114 (13): 3509-3514.
Setiawan E, Wilson AA, Mizrahi R, Rusjan PM, Miler L, Rajkowska G, Suridjan I, Kennedy JL, Rekkas PV, Houle S, Meyer JH. Increased translocator protein distribution volume, a marker of microglial activation, in the brain during major depressive episodes. JAMA Psychiatry 2015; 72(3):268-275.
Rekkas PV, Wilson AA, Houle, S, Rusjan, P, Stewart, DE, & Meyer, J.H. Greater Monoamine Oxidase A binding in perimenopausal age as measured with carbon 11-labeled harmine positron emission tomography. JAMA Psychiatry 2014; 71(8):873-9.
Sacher J, Wilson AA, Houle S, Hassan S, Rusjan P, Bloomfield P, Stewart D, Meyer JH. Elevated brain Monoamine Oxidase A binding in human early postpartum. Arch Gen Psych 2010; 67(5):468-74.
Meyer JH, Wilson AA, Sagrati S, Miler L, Rusjan P, Bloomfield PM, Clark M, Sacher J, Voineskos AN, Houle S. Brain Monoamine Oxidase A binding in major depressive disorder: Relationship to selective serotonin reuptake inhibitor treatment, recovery and recurrence. Arch Gen Psych 2009; 66(12): 1304-1312.
Praschak-Rieder N, Willeit M, Wilson AA, Houle S, Meyer JH. Season, sunlight and serotonin transporters in living human brain. Arch Gen Psych 2008; 65(9): 1072-1078.
Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D, Garcia A, Young LT, Praschak-Rieder N, Wilson AA, Houle S. Elevated brain Monoamine Oxidase A: An explanation for the monoamine imbalance of major depression. Arch Gen Psych 2006; 63(11): 1209-1216.
Meyer JH, McNeely H, Sagrati S, Boovariwala A, Martin K, Verhoeff NPLG, Wilson AA, Houle S. Striatal D2 receptor binding potential and its relationship to motor retardation in major depression. Am J Psychiatry 2006; 163(9):1594-602.
Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, Houle S. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: An [11C] DASB positron emission tomography study. Am J Psychiatry 2004; 161(5): 826-35.
Meyer JH, McMain S, Kennedy SH, Korman L, Brown GM, DaSilva JN, Wilson AA, Blak T, Eynan-Harvey R, Goulding VS, Houle S, Links P. Dysfunctional attitudes and serotonin 2 receptors during depression and self-harm. Am J Psychiatry 2003; 160(1):90-9.
Centre for Addiction and Mental Health
250 College Street, 11th Floor
Toronto, ON M5T 1R8
Telephone: 416-535-8501 X34007