Faculty: Jose N. Nobrega, PhD
Professor, Pharmacology, Psychiatry and Psychology
Senior Scientist and Head, Behavioral Neurobiology Laboratory
Research Imaging Centre, Centre for Addiction and Mental Health (CAMH)
General Research Areas: Neuropharmacology; Behavioural Pharmacology; Neuroreceptors and Behaviour
Research is focused on regional brain differences in neuroreceptor regulatory mechanisms both in normal and pathological conditions. To this end, receptor autoradiographic techniques, in situ hybridization and quantitative immunohistochemistry are used in preclinical models. Current projects include regional brain changes induced by: (a) drugs of abuse; (b) treatments used in neuropsychiatric conditions including pharmacological agents and deep brain stimulation; and (c) specific behavioural states, including stress-induced behaviours, impulse control and movement disorders. Neurochemical systems currently studied in these preparations include dopamine, norepinephrine, serotonin, acetylcholine, GABA and glutamate.
Wheeler AL, Creed MC, Voineskos AN, Nobrega JN. Changes in brain functional connectivity after chronic haloperidol in rats: a network analysis. Intl J Neuropsychopharmacol., 2014, in press.
Nona C, Guirgis S, Nobrega JN. Susceptibility to ethanol sensitization is differentially associated with changes in pCREB, trkB and BDNF mRNA expression in mouse brain. Behav Brain Res. 2013, 242, 25-33.
Aleksandrova L, Creed MC, Fletcher PJ, Lobo DSS, Hamani C, Nobrega JN. Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task. Behav Brain Res. 2013, 245, 76-82.
Hamani C, Nobrega JN. Preclinical studies modeling deep brain stimulation for depression. Biol Psychiat. 2012, 72, 916-923.
Hamani C, Machado DC, Hipólide DC, Dubiela FP, Nobrega JN. Deep brain stimulation reverses anhedonic-like behaviour in a chronic stress model of depression – Role of serotonin and brain-derived neurotrophic factor. Biol Psychiat. 2012, 71, 30-35.
Creed MC, Hamani C, Bridgman A, Fletcher PJ, Nobrega JN. Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nuclei. J Neurosci. 2012, 32, 9574-9581.
Centre for Addiction & Mental Health
Behavioural Neurobiology Laboratory
Research Imaging Centre
250 College Street
Phone:  535-8501. Ext. 6259
FAX:  979-4739