Pharmacology and Toxicology

Faculty: Krista L. Lanctôt, PhD

Krista L. Lanctôt, PhDKrista L. Lanctôt, PhD
Professor of Pharmacology, Psychiatry, University of Toronto
Director, Neuropsychopharmacology, Sunnybrook Health Sciences Centre

General Research Areas: Clinical Pharmacology, Neuropharmacology/Psychopharmacology,
Pharmacoeconomics.

Dementia and other neurologic disorders are frequently accompanied by neuropsychiatric symptoms such as aggression, agitation, apathy, depressive symptoms and sleep disturbances. The reason for these symptoms is unknown. Our research aims to elucidate the neurobiology and neuropathology of behavioural disorders associated with neurologic disorders to allow us to understand and predict treatment response. We also look at how medications used to treat behavioural disorders work on the brain.

A second focus is outcomes research, for example how current pharmacotherapies will impact quality of life and interactions between herbal medications used by patients with dementia and prescribed medications.

 

PubMed

Selected Publications: (Prof. Lanctôt's students are indicated in bold)

  1. Liu C, Adibfar A, Herrmann N, Gallagher D, Lanctôt KL.  Evidence for Inflammation-Associated Depression.  Curr Top Behav Neurosci. 2017;31:3-30. doi: 10.1007/7854_2016_2 PMID: 27221622 senior responsible author
     
  2. Lanctôt KL, Agüera-Ortiz L, Brodaty H, Francis PT, Geda YE, Ismail Z, Marshall GA, Mortby ME, Onyike CU, Padala PR, Politis AM, Rosenberg PB, Siegel E, Sultzer DL, Abraham EH.  Apathy associated with neurocognitive disorders: recent progress and future directions Alzheimers Dement. 2017 Jan;13(1):84-100. doi: 10.1016/j.jalz.2016.05.008. Review PMID: 27362291 corresponding author
     
  3. Mazereeuw G, Herrmann N, Andreazza AC, Scola G, Ma D, Oh PI, Lanctôt KL.  Oxidative stress predicts depressive symptom changes with omega-3 fatty acid treatment in coronary artery disease patients. Brain Behav Immun 2017 Feb;60:136-141. doi: 10.1016/j.bbi.2016.10.005 PMID: 27742581 corresponding author
     
  4. Wang DY, Li A, Paes BA, Mitchell I, Lanctôt KL and the CARESS Investigators.  First versus second-year respiratory syncytial virus prophylaxis in chronic lung disease (2005-2015). Eur J Pediatr 2017 Mar;176(3):413-22 doi: 10.1007/s00431-017-2849-4. PMID 28105526 corresponding author
     
  5. Dinoff A, Herrmann N, Lanctôt KL. Ceramides and depression: a systematic review. J Affect Disord. 2017 Feb 7;213:35-43. doi: 10.1016/j.jad.2017.02.008. [Epub ahead of print] Review PMID 28189963 corresponding author  
     
  6. Santiago C, Herrmann N, Swardfager W, Saleem M, Oh PI, Black SE, Bradley J, Lanctôt KL. Subcortical hyperintensities in the cholinergic system affect improvements in executive function in older adults with coronary artery disease undergoing cardiac rehabilitation. Int J Geriatr Psychiatry 2018 Jan; 33(1): 279–287. doi: 10.1002/gps.4729.  Epub 2017 May 5 PMID: 28474775
     
  7. Chan P, Suridjan I, Mohammad D, Herrmann N, Mazereeuw G, Hillyer LM, Ma DWL, Oh PI, Lanctôt KL. Novel phospholipid signature of depressive symptoms in patients with coronary artery disease. J Am Heart Assoc. 2018 May 5;7(10). pii: e008278. doi: 10.1161/JAHA.117.008278 PMID: 29730646
     
  8. Chau SA, Herrmann N, Chung J, Eizenman M, Lanctôt KL.  Effect of methylphenidate for apathy on visual attention scanning behavior: a pilot study. Can Geriatr J 2018 Jun 30;21(2):139-142. doi: 10.5770/cgj.21.291. eCollection 2018 Jun PMID: 29977428
     
  9. Moss J, Nauranga D, Rosen M, Kim D, Wang K, Lanctôt KL. Variation in admission rates between psychiatrists on call in a university teaching hospital. Ann Gen Psychiatry 2018 Jul 10;17:30. doi: 10.1186/s12991-018-0199-x. eCollection 2018. PMID: 30008791
     
  10. Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctôt KL. Ceramide accumulation is associated with declining verbal memory in coronary artery disease patients: an observational study. J Alzheimers Dis 2018 Jul 26;64(4):1235-1246. doi: 10.3233/JAD-180030 PMID: 30010121
     
  11. Rosen M, Chan P, Saleem M, Herrmann N, Adibfar A, Andreazza A, Oh P, Lanctôt KL. Longitudinal associations between 4-hydroxynonenal and depression in coronary artery disease patients Psychiatry Res. 2018 Dec;270:219-224. doi: 10.1016/j.psychres.2018.09.046. Epub 2018 Sep 21 PMID: 30267986
     
  12. Saleem M, Herrmann N, Dinoff A, Mazereeuw G, Oh PI, Goldstein BI, Shammi P, Lanctôt KL. Association between endothelial function and cognitive performance in patients with coronary artery disease during cardiac rehabilitation. Psychosom Med. 2019 Feb/Mar;81(1):184-191. doi: 10.1097/PSY.0000000000000651. Epub 2018 Oct 28 PMID: 30383709


Contact:

Sunnybrook Health Sciences Centre 
Neuropsychopharmacology Research 
Room FG-08, 2075 Bayview Avenue 
Toronto, Ontario  M4N 3M5 
Phone: [416]480-6100 X2241 
FAX: [416]480-6022 
Email: krista.lanctot@sunnybrook.ca