Faculty: Krista L. Lanctot, PhD

Krista L. Lanctôt, PhDKrista L. Lanctôt, PhD
Professor of Pharmacology, Psychiatry, University of Toronto
Director, Neuropsychopharmacology, Sunnybrook Health Sciences Center

General Research Areas: Clinical Pharmacology, Neuropharmacology/Psychopharmacology,
Pharmacoeconomics.

Dementia and other neurologic disorders are frequently accompanied by neuropsychiatric symptoms such as aggression, agitation, apathy, depressive symptoms and sleep disturbances. The reason for these symptoms is unknown. Our research aims to elucidate the neurobiology and neuropathology of behavioural disorders associated with neurologic disorders to allow us to understand and predict treatment response. We also look at how medications used to treat behavioural disorders work on the brain.

A second focus is outcomes research, for example how current pharmacotherapies will impact quality of life and interactions between herbal medications used by patients with dementia and prescribed medications.

 

PubMed

Selected Publications: (Prof. Lantôt's students are indicated in bold)

1.           Dinoff A, Herrmann N, Swardfager W, Liu CS, Sherman C, Chan S, Lanctôt KL.  The effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): A Meta-analysis. PLoS One  2016 Sep 22;11(9):e0163037. doi: 10.1371/journal.pone.0163037. eCollection 2016 PMID: 27658238 corresponding author

2.           Mazereeuw G, Herrmann N, Oh PI, Ma D, Wang CT, Kiss A, Lanctôt KL.  Omega-3 fatty acids, depressive symptoms and cognitive performance in coronary artery disease patients: a randomized, double-blind, placebo-controlled trial. J Clin Psychopharmacol. 2016 Oct;36(5):436-44. doi: 10.1097/JCP.0000000000000565 PMID: 27529771 corresponding author

3.           Liu CS, Ruthirakuhan M, Chau SA, Herrmann N, Carvalho AF, Lanctôt KL.  Pharmacological management of agitation and aggression in Alzheimer's disease: a review of current and novel treatments. Curr Alzheimer Res. 2016 Oct;13(10):1134-1144. Review. PMID: 27137221 corresponding author

4.           Rej S, Saleem M, Herrmann N, Stefatos A, Rau A, Lanctôt KL. Serum LDL levels, statin use and cognition in patients with coronary artery disease. Neuropsychiatr Dis Treat.  2016 Nov 10;12:2913-2920 PMID: 27877045 corresponding author

5.           Ruthirakuhan M, Herrmann N, Suridjan I, Farber I, Lanctôt KL.  Beyond immunotherapy: new approaches for disease modifying treatments for early Alzheimer's disease. Expert Opin Pharmacother 2016 Dec;17(18):2417-2429 PMID: 27825018 corresponding author

6.           Chau S, Herrmann N, Sherman C, Chung J, Eizenman M, Kiss A, Lanctôt KL. Visual selective attention towards novel stimuli predicts cognitive decline in Alzheimer’s disease patients.  J Alzheimers Dis. 2017 Jan;55(4):1339-1349. doi: 10.3233/JAD-160641. PMID: 27834775 corresponding author

7.           Liu C, Adibfar A, Herrmann N, Gallagher D, Lanctôt KL.  Evidence for Inflammation-Associated Depression.  Curr Top Behav Neurosci. 2017;31:3-30. doi: 10.1007/7854_2016_2 PMID: 27221622 senior responsible author

8.           Lanctôt KL, Agüera-Ortiz L, Brodaty H, Francis PT, Geda YE, Ismail Z, Marshall GA, Mortby ME, Onyike CU, Padala PR, Politis AM, Rosenberg PB, Siegel E, Sultzer DL, Abraham EH.  Apathy associated with neurocognitive disorders: recent progress and future directions Alzheimers Dement. 2017 Jan;13(1):84-100. doi: 10.1016/j.jalz.2016.05.008. Review PMID: 27362291 corresponding author

9.           Mazereeuw G, Herrmann N, Andreazza AC, Scola G, Ma D, Oh PI, Lanctôt KL.  Oxidative stress predicts depressive symptom changes with omega-3 fatty acid treatment in coronary artery disease patients. Brain Behav Immun 2017 Feb;60:136-141. doi: 10.1016/j.bbi.2016.10.005 PMID: 27742581 corresponding author

10.        Wang DY, Li A, Paes BA, Mitchell I, Lanctôt KL and the CARESS Investigators.  First versus second-year respiratory syncytial virus prophylaxis in chronic lung disease (2005-2015). Eur J Pediatr 2017 Mar;176(3):413-22 doi: 10.1007/s00431-017-2849-4. PMID 28105526 corresponding author

11.        Gallagher D, Kiss A, Lanctôt K, Herrmann N. Depression with inflammation: longitudinal analysis of a proposed depressive subtype in community dwelling older adults. Int J Geriatr Psychiatry 2016 Dec 2. doi: 10.1002/gps.4645. [Epub ahead of print] PMID: 27911015 co-author

12.        Dinoff A, Herrmann N, Lanctôt KL. Ceramides and depression: a systematic review. J Affect Disord. 2017 Feb 7;213:35-43. doi: 10.1016/j.jad.2017.02.008. [Epub ahead of print] Review PMID 28189963 corresponding author  

Contact:

Sunnybrook Health Sciences Centre 
Neuropsychopharmacology Research 
Room FG-08
2075 Bayview Avenue 
Toronto, Ontario 
M4N 3M5 
Phone: [416]480-6100 X2241 
FAX: [416]480-6022 
Email: krista.lanctot@sunnybrook.ca

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