Faculty: Laszlo Endrenyi, PhD

Laszlo Endrenyi, PhDLaszlo Endrenyi, PhD
Professor Emeritus

General Research Area: Pharmacokinetics
Assessment of Bioequivalence and Bioavailability of Drugs, Biosimilarity


 Selected Publications:

 L. Endrenyi and P. Al-Shaikh. (1995).  Sensitive and specific determination of the equivalence of absorption rates.  Pharm.  Res. 12, 1856-1864.

 L. Tothfalusi and L. Endrenyi.  (2003).  Limits for the scaled average bioequivalence of highly variable drugs and drug products.  Pharm. Res. 20, 382-389.

 L. Tothfalusi, L. Endrenyi, and A. Garcia Arieta.  (2009).  Evaluation of bioequivalence for highly-variable drugs with scaled average bioequivalence. Clin. Pharmacokin., 48, 725-743.

L. Tothfalusi and L. Endrenyi. (2011).  Sample sizes for designing bioequivalence studies for highly variable drugs.  J. Pharm. Pharmaceut. Sci. 15: 73-84.

L. Endrenyi, S.C. Chow, C. Chang, and L. Tothfslusi. (2012). On the interchangeability of biologic drug products. Stat. Medicine, 32: 434-441.

 L. Endrenyi and L. Tothfalusi. (2012).  Metrics for the evaluation of bioequivalence of modified release formulations.  AAPS J. 14: 813-819.

 S.C. Chow, J. Wang, L. Endrenyi, and P.A. Lachenbruch. (2012). Scientific considerations for assessing biosimilar products.  Stat. Medicine, 32: 370-381.

L. Endrenyi and L. Tothfalusi. (2013). Determination of bioequivalence for drugs with narrow therapeutic index: reduction of the regulatory burden.  J. Pharm  Pharmaceut. Sci. 16: 676-682.

 S.C. Chow, L. Endrenyi, P.A. Lachenbruch, and F. Mentre. (2014).  Scientific factors and current issues in biosimilar studies. J. Biopharm. Stat. 24: 1138-1153.

L. Tothfalusi and L. Endrenyi. (2016). An exact procedure for the evaluation of reference scaled average bioequivalence.  AAPS J. 18(2): 476-489.

L. Endrenyi, H.H. Blume, and L. Tothfalusi. (2017). The two main goals of bioequivalence studies. AAPS J., e-preprint.

L. Endrenyi, P.J. Declerck, and S.C. Chow. (2017)  Biosimilar drug product development. CRC Press/Taylor & Francis, London-New York, pp. 477.


Contact Information:
Department of Pharmacology and Toxicology
Email: l.endrenyi@utoronto.ca

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