Faculty: Martin Zack, PhD
Assistant Professor, Pharmacology
Scientist, Cognitive Psychopharmacology Laboratory, Center for Addiction and Mental Health
General Research Areas: Drug Addiction, Neuropharmacology/Psychopharmacology
Psychopharmacology of Cognition and Motivational Processes in Addicted Populations
My research examines the neurobiological basis of pathological gambling as well as similarities and differences with substance use disorders. I use drugs that target specific neurotransmitters and receptor sites to reveal their impact on processes linked with addictive thought processes and motivation in human participants with addictive disorders and healthy volunteers. I also collaborate with investigators who use positron emission tomography (PET) and non-invasive brain stimulation to assess and manipulate neurotransmission on-line.
Boileau I, Payer D, Chugani B, Lobo DS, Houle S, Wilson AA, Warsh J, Kish SJ, Zack M. In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [11C]-(+)-PHNO. Mol Psychiatry. 2013 Dec 10. doi: 10.1038/mp.2013.163. [Epub ahead of print]
Smart K, Desmond RC, Poulos CX, Zack M. Modafinil increases reward salience in a slot machine game in low and high impulsivity pathological gamblers.Neuropharmacology. 2013 Oct;73:66-74. doi: 10.1016/j.neuropharm.2013.05.015. Epub 2013 May 24.
Boileau I, Payer D, Houle S, Behzadi A, Rusjan P, Tong J, Wilkins D, Selby P, George T, Zack M, et al. Higher binding of the dopamine D3 receptor-preferring ligand [11C]-(+)-PHNO in methamphetamine polydrug users: a positron emission tomography study. J Neurosci. 2012, 32, 1353-1359.
Zack M, Aramakis B, Khamba B, MacLeod CM, Poulos CX. Alcohol selectively impedes negative self-relevant associations in young drinkers. J Psychopharmacol. 2012 Feb;26(2):221-31. doi: 10.1177/0269881111416690. Epub 2011 Sep 2.
Steinberg L, Tremblay AM, Zack M, Busto UE, Zawertailo LA. Effects of stress and alcohol cues in men with and without gambling and alcohol use disorders. Drug Alcohol Depend. 2011 Dec 1;119(1-2):46-55. doi: 10.1016/j.drugalcdep.2011.05.011. Epub 2011 Jun 11.
Zack M, Woodford, TM, Tremblay AM, Steinberg L, Zawertailo LA, Busto UE. Stress and alcohol cues exert conjoint effects on go and stop signal responding in male problem drinkers. Neuropsychopharmacology. 2011, 36, 445-458.
Tremblay AM, Desmond RC, Poulos CX, Zack M. Haloperidol modifies instrumental aspects of slot machine gambling in pathological gamblers and healthy controls. Addict Biol. 2011 Jul;16(3):467-84.
Cognitive Pharmacology Laboratory
Centre for Addiction and Mental Health
33 Russell Street
Canada M5S 2S1
Phone: (416) 535-8501, ext. 36052
FAX: (416) 595-6618