Faculty: Masoud Vedadi, PhD

Masoud Vedadi, PhDMasoud Vedadi, PhD
Assistant Professor, Pharmacology & Toxicology
Principal Investigator, Molecular Biophysics, Structural Genomics Consortium

General Research Area: Epigenetics - Chemical Probes for Drug Discovery.

In Molecular Biophysics group we characterize proteins produced by the SGC scientists in Toronto and also focus on developing new high throughput biophysical and biochemical characterization and screening methods. We are particularly interested in developing chemical probes for epigenetic targets. By screening proteins against customized chemical libraries, we identify small molecules that inhibit / bind to these proteins that could be used in developing chemical probes for epigenetic targets in collaboration with chemistry partners and other SGC groups.  Creating and comparing chemical profiles for members of each family of protein along with functional studies, we investigate the structure-function relationship and identify unique inhibitors that can discriminate among members of each family of protein.
 

Selected Publications:

  1. Masoud Vedadi*, Levi Blazer, Mohammad S. Eram, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, and Taraneh Hajian (2017) Targeting human SET1/MLL family of proteins. Protein science. PMID: 28160335.
  2. Blazer LL, Li F, Kennedy S, Zheng YG, Arrowsmith CH, Vedadi M*. (2016) A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D. J. Biomol. Screen. PMID: 27581605.
  3. Zhao DY, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, Vedadi M, Min J, Pawson TJ, Blencowe BJ, Greenblatt JF. (2016) SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature. 529(7584):48-53. PMID: 26700805.
  4. Blazer LL, Lima-Fernandes E, Gibson E, Eram MS, Loppnau P, Arrowsmith CH, Schapira M, Vedadi M*. (2016) PR Domain-Containing Protein 7 (PRDM7) is a Histone 3 Lysine 4 Trimethyltransferase. J. Biol. Chem. PMID: 27129774.
  5. Ss Zhu J, Sammons MA, Donahue G, Dou Z,Vedadi M, Getlik M, Barsyte-Lovejoy D,Al-awar R, Katona BW, Shilatifard A, Huang J, Hua X, Arrowsmith CH, Berger SL (2015) Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature. PMID: 26331536.
  6. Grebien F*, Vedadi M*, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G. (2015) Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nat. Chem. Biol. PMID: 26167872.
  7. H. Ümit Kaniskan, Magdalena M. Szewczyk, Zhengtian Yu, Mohammad S. Eram, Xiaobao Yang, Keith Schmidt, Xiao Luo, Miao Dai, Feng He, Irene Zang, Ying Lin, Steven Kennedy, Fengling Li, Elena Dobrovetsky, Aiping Dong, David Smil, Sun-Joon Min, Melissa Landon, Jennifer Lin-Jones, Xi-Ping Huang, Bryan L. Roth, Matthieu Schapira, Peter Atadja, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Peter J. Brown, Kehao Zhao, Jian Jin* and Masoud Vedadi* (2015) A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3). Angew. Chem. Int. Ed. Engl. PMID: 25728001.
  8. Barsyte-Lovejoy D*, Li F, Oudhoff MJ, Tatlock JH, Dong A, Zeng H, Wu H, Freeman SA, Schapira M, Senisterra GA, Kuznetsova E, Marcellus R, Allali-Hassani A, Kennedy S, Lambert JP, Couzens AL, Aman A, Gingras AC, Al-Awar R, Fish PV, Gerstenberger BS, Roberts L, Benn CL, Grimley RL, Braam MJ, Rossi FM, Sudol M, Brown PJ, Bunnage ME, Owen DR, Zaph C, Vedadi M*, Arrowsmith CH* (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc. Natl. Acad. Sci. U S A. PMID:  25136132
  9. Mohammad S. Eram, Susan P. Bustos, Evelyne Lima-Fernandes, Alena Siarheyeva, Guillermo Senisterra, Taraneh Hajian, Irene Chau, Shili Duan, Hong Wu, Ludmila Dombrovski, Matthieu Schapira, Cheryl H. Arrowsmith and Masoud Vedadi* (2014) Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9. J. Biol. Chem. PMID: 24634223.
  10. Andreas Ernst, George Avvakumov, Jiefei Tong, Yihui Fan, Yanling, Zhao, Philipp Alberts, Avinash Persaud, John R. Walker, Ana-Mirela Neculai, Dante Neculai, Andrew Vorobyov, Pankaj Garg, Linda Beatty, Pak-Kei Chan, Yu-Chi Juang, Marie-Claude Landry, Christina Yeh6, Elton Zeqiraj, Konstantina Karamboulas, Abdellah Allali-Hassani, Masoud Vedadi, Mike Tyers, Jason Moffat, Frank Sicheri, Laurence Pelletier, Daniel Durocher, Brian Raught, Daniela Rotin, Jianhua Yang, Michael F. Moran, Sirano Dhe-Paganon and Sachdev S. Sidhu (2013) A Strategy for Modulation of Enzymes in the Ubiquitin System. Science. PMID:  23287719.
  11. Guillermo Senisterra, Hong Wu,Abdellah Allali-Hassani, Gregory A Wasney, Dalia Barsyte-Lovejoy, Ludmila Dombrovski, Aiping Dong, Kong T. Nguyen, David Smil, Yuri Bolshan, Taraneh Hajian, Hao He, Alma Seitova, Irene Chau, Fengling Li, Gennadiy Poda, Jean-François Couture, Peter J. Brown, Rima Al-awar, Matthieu Schapira, Cheryl H. Arrowsmith and Masoud Vedadi* (2012) Small molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem. J., PMID: 22989411.
  12. Alena Siarheyeva, Guillermo Senisterra, Abdellah Allali-Hassani, Aiping Dong, Elena Dobrovetsky, Gregory Wasney, Irene Chau, Richard Marcellus, Taraneh Hajian, Feng Liu, Ilia Korboukh, David Smil, Yuri Bolshan, Jinrong Min, Hong Wu, Hong Zeng, Peter Loppnau, Gennadiy Poda, Carly Griffin, Ahmed Aman, Peter J. Brown, Jian Jin, Rima Al-awar, Cheryl Arrowsmith, Matthieu Schapira and Masoud Vedadi* (2012) An Allosteric Inhibitor of Protein Arginine Methyltransferase 3. Structure. PMID: 22795084

Contact:

MaRS Centre, South Tower
101 College Street, 7th floor, Rm. 714 
Toronto, Ontario 
M5G 1L7 
Phone: 416-946-0897
FAX: 416-946-0588
Email: m.vedadi@utoronto.ca

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