Faculty: Michelle Arnot, PhD
Associate Professor, Teaching Stream
General Research Areas: Neuropharmacology, Cadiovascular Pharmacology, Receptor Pharmacology
NOT TAKING GRADUATE STUDENTS
My research interests include understanding the role of ion channels in the brain and cardiac cells, and their potential as targets by a variety of drugs. More specifically I am interested in the physiological alterations that occur following chronic drug stimulation of these ion channels. Although my most recent research has involved voltage-gated calcium channels, I also continue to be interested in the GABA-A receptor and its modulation within the brain.
My educational scholarship interests include examining how students learn in “science” courses and how this learning may be altered by various pedagogical practices. More specifically, I am interested in how to engage students in the role that pharmacology/toxicology play in society at large.
Hui K, Arnot MI, Shin HS, Sun HS, and Feng ZP. Functional channel expression of voltage-gated calcium channels in Neonatal Rat Myocytes following Chronic PKA Modulation. Channels. (In press).
Arnot JA, Arnot MI, Mackay D, Couillard Y, MacDonald D, Bonnell M, Doyle P. Molecular size cut-off criteria for assessing bioaccumulation potential: fact or fiction? Integr Environ Assess Manag. 2010; 6(2): 210-224.
Doering C.J., Kisilevsky A.E., Feng Z-P., Arnot M.I., Peloquin J, Hamid J, Barr W, Nirdosh A, Simms B, Winkfein R.J., and. Zamponi G.W. A single Gβ subunit locus controls crosstalk between PKC and G protein regulation of N-type calcium channels . J. Biol. Chem. 2004; 279(28):29709-17
*Arnot MI, *Feng Z-P, Doering CJ, and Zamponi GW. Calcium channel β subunits differentially regulate the inhibition of N-type channels by individual Gβ isoforms. J. Biol. Chem. 2001; 276(48):45051-8.
Arnot MI, Davies M, Martin IL, and Bateson AN. Chronic diazepam and GABAA receptor gene expression and binding characteristics: differential alterations with two different treatment regimes. J. Neurosci. Res. 2001; 64(6):617-25.
Cooper CC, Arnot MI, Feng ZP, Hamid J, and Zamponi GW. T422E mutation in the α1B calcium channel II-III linker alters affinity for Gβ1 subunit. J. Biol. Chem.2000; 275(52):40777-40789
Magga JM, Jarvis SE, Arnot MI, Zamponi GW, and Braun JEA. Cysteine string protein regulates G-protein modulation of N-type calcium channels. Neuron. 2000; 28(1):195-204
Arnot MI, Stotz SC, Jarvis SE, and Zamponi GW. Differential modulation of N-type α1B and P/Q-type α1A calcium channels by different G protein β subunit isoforms. J. Physiol. 2000; 527(2):203-212.
Contact Address: University of Toronto
Department of Pharmacology and Toxicology
Rm. 4219, Medical Sciences Building
1 King's College Circle