Faculty: Norton W. Milgram, PhD
General Research Area: Neuropharmacology and BehaviorPharmacological Modification of Cognitive Function in the Aged Dog
Not taking new graduate students
Tapp, PD Kevin Head, Elizabeth Head, Norton W. Milgram, Bruce A. Muggenburg, and Min-Ying Su . Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. NeuroImage, 2006, 29:234-244.
Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 2006 Apr 5;24(15):2824-34. Epub 2006 Jan 19.
Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Res Rev. 2006 Aug; 5(3):354-69.
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiol Aging. 2008 Jan;29(1):39-50. Epub 2006 Nov 7.
Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiol Aging. 2008 Jan;29(1):51-70. Epub 2006 Oct 20.
Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW Neurobiol Learn Mem. 2006 Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem. 2006 Sep;86(2):197-204.
Christie L-A, Studzinski C, Araujo J, Leung C, Ikeda-Douglas C, Head E, Cotman CW, and Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Progress in Neuropsychopharmacol and Biol. Psychiat. 2005, 29:361-369.
Studzinski, CM, Araujo, J and Milgram, NW. The Canine Model of Human Cognitive Aging and Dementia: Pharmacological Validity of the Model for Assessment of Human Cognitive-Enhancing. Progress in Neuropsychopharmacol. and Biol. Psychiat. 2005, 29:489-498; Review.
Araujo, JA., Studzinski, CM, and Milgram, NW. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in Neuropsychopharmacol. and Biol. Psychiat. 2005, 29, 411-422, Review.
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