Faculty: Subodh Verma, MD, PhD, FRCSC, FAHA

Subodh Verma, MD, PhD, FRCSC, FAHASubodh Verma, MD, PhD, FRCSC, FAHA
Cardiac Surgeon, St Michael's Hospital 
Professor, Institute of Medical Sciences & Department of Pharmacology & Toxicology
Canada Research Chair in Atherosclerosis

General Research Areas: Biochemical & Molecular Pharmacology; Cardiovascular Pharmacology; Endocrine Pharmacology; Immunopharmacology; Endothelial Biology and Cardio-oncology

  • Basic and translational aspects of endothelial biology as they relate to inflammation and vascular diseases
  • Role of DNA-damage repair genes in normal and abnormal cardiovascular physiology.
     

Selected Publications:

Yau JW, Singh KK, Hou Y, Lei X, Ramadan A, Quan A, Teoh H, Kuebler WM, Al-Omran M, Yanagawa
B, Ni H, Verma S. (2017). Endothelial-specific deletion of autophagy related 7 (ATG7) attenuates arterial
thrombosis in mice. J Thorac Cardiovasc Surg. doi: 10.1016/j.jtcvs.2017.02.058.

Shi X, Verma S, Yun J, Brand-Arzamendi K, Singh KK, Liu X, Garg A, Quan A, Wen X-Y. (2016). Effect
of empagliflozin on cardiac biomarkers in a zebrafish model of heart failure: Clues to the EMPA-REG
OUTCOME trial?. Mol Cell Biochem. 2017 Apr 8. doi: 10.1007/s11010-017-3018-9.

Ramadan A, Al-Omran M, Verma S. (2017). The putative role of autophagy in the pathogenesis of
abdominal aortic aneurysms. Atherosclerosis. 257: 288-296.

Verma S, Garg A, Yan AT, Gupta AK, Al-Omran M, Sabongui A, Teoh H, Mazer CD, Connelly KA. (2016).
Effect of empagliflozin on left ventricular mass and diastolic function in individuals with diabetes: An
important clue to EMPA-REG OUTCOME trial? Diabetes Care. 39(12): e212-e213.

Torisu K, Singh KK, Torisu T, Lovren F, Liu J, Pan Y, Quan A, Ramadan A, Al-Omran M, Pankova N,
Boyd SR, Verma S, Finkel T. (2016). Intact endothelial autophagy is required to maintain vascular lipid
homeostasis. Aging Cell. 15: 187-91.

Ehsan M, Singh SS, Lovren F, Pan Y, Quan A, Mantella LE, Sandhu P, Teoh H, Al-Omran M, Verma S.
(2016). Adiponectin Limits Monocytic Microparticle-Induced Endothelial Activation by Modulation of the
AMPK, Akt and NFkB Signaling Pathways. Atherosclerosis. 245: 1-11.

Singh KK, Lovren F, Pan Y, Quan A, Ramadan A, Matkar PN, Ehsan M, Sandhu P, Mantella LE, Gupta
N, Teoh H, Parotto M, Tabuchi A, Kuebler WM, Al-Omran M, Finkel T, Verma S. (2015). The essential
autophagy gene ATG7 modulates organ fibrosis via regulation of endothelial-to-mesenchymal transition. J
Biol Chem. 290(5): 2547-2559.

Nussenzweig SC, Verma S, Finkel T. (2015). The role of autophagy in vascular biology. Circ Res. 116:
480-488.

Verma S , Lovren F , Pan Y , Yanagawa B , Deb S , Karkhanis R , Quan A , Teoh H , Feder-Elituv R ,
Moussa F , Souza DS , Fremes SE. (2014). Pedicled no-touch saphenous vein graft harvest limits vascular
smooth muscle cell activation: the PATENT saphenous vein graft study.Eur J Cardiothoracic Surg. 45(4): 717-25.

Singh KK , Yanagawa B , Quan A , Wang R , Garg A , Khan R , Pan Y , Wheatcroft MD , Lovren F , Teoh
H , Verma S. (2014). Autophagy gene fingerprint in human ischemia and reperfusion.J Thoracic Cardiovasc Surg. 147(3): 1065-1072.

Lovren F , Pan Y , Quan A , Singh KK , Khan R , Gupta N , Brezden-Masley C , Teoh H , Wheatcroft MD ,
Al-Omran M , Verma S. (2014). BRCA1 shields vascular smooth muscle cells from oxidative stress.J
Thorac Cardivovasc Surg. 147(6): 1946-1955.

Trop S , Marshall JC , Mazer CD , Gupta M , Dumont DJ , Bourdeau A , Verma S. (2014). Perioperative
cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with
prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytes.J Surg Res. 187(1): 43-52.

Contact:

Division of Cardiac Surgery 
St Michael’s Hospital 
30 Bond Street 
8th Floor, Bond Wing 
Toronto, Ontario 
M5B 1W8 
Telephone 416-864-5997 
Fax 416-864-5881 
Email: vermasu@smh.ca 

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