Faculty: Subodh Verma, MD, PhD, FRCSC, FAHA

Subodh Verma, MD, PhD, FRCSC, FAHASubodh Verma, MD, PhD, FRCSC, FAHA
Cardiac Surgeon, St Michael's Hospital 
Professor, Institute of Medical Sciences & Department of Pharmacology & Toxicology
Canada Research Chair in Atherosclerosis

General Research Areas: Biochemical & Molecular Pharmacology; Cardiovascular Pharmacology; Endocrine Pharmacology; Immunopharmacology; Endothelial Biology and Cardio-oncology

  • Basic and translational aspects of endothelial biology as they relate to inflammation and vascular diseases
  • Role of DNA-damage repair genes in normal and abnormal cardiovascular physiology.
     

Selected Publications:

Verma S, Siu SC. Aortic dilatation in patients with bicuspid aortic valve. N Engl J Med. 2014 May 15;370(20):1920-9. PMID: 24827036.

Singh KK, Yanagawa B, Quan A, Wang R, Garg A, Khan R, Pan Y, Wheatcroft MD, Lovren F, Teoh H, Verma S. Autophagy gene fingerprint in human ischemia and reperfusion J Thorac Cardiovasc Surg. 2014 Mar;147(3):1065-1072. PMID: 23778083

Teoh H, Quan A, Creighton AK, Annie Bang KW, Singh KK, Shukla PC, Gupta N, Pan Y, Lovren F, Leong-Poi H, Al-Omran M, Verma S.  BRCA1 gene therapy reduces systemic inflammatory response and multiple organ failure and improves survival in experimental sepsis.. Gene Ther. 2013 Jan;20(1):51-61. PMID: 22257935.

Singh KK, Shukla PC, Quan A, Desjardins JF, Lovren F, Pan Y, Garg V, Gosal S, Garg A, Szmitko PE, Schneider MD, Parker TG, Stanford WL, Leong-Poi H, Teoh H, Al-Omran M, Verma S. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. J Biol Chem. 2012 Feb 24;287(9):6604-14. PMID: 22157755.

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta N, Steer BM, Ingram AJ, Gupta M, Al-Omran M, Teoh H, Marsden PA, Verma S. MicroRNA-145 targeted therapy reduces atherosclerosis. Circulation. 2012 Sep 11;126(11 Suppl 1):S81-90. PMID: 22965997.

Shukla PC, Singh KK, Quan A, Al-Omran M, Teoh H, Lovren F, Cao L, Rovira II, Pan Y, Brezden-Masley C, Yanagawa B, Gupta A, Deng CX, Coles JG, Leong-Poi H, Stanford WL, Parker TG, Schneider MD, Finkel T, Verma S. BRCA1 is an essential regulator of heart function and survival following myocardial infarction. Nat Commun. 2011 Dec 20;2:593. PMID: 22186889.

Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, Al-Omran M, Teoh H, Verma S. Adropin is a novel regulator of endothelial function. Circulation. 2010 Sep 14;122(11 Suppl):S185-92. PMID: 20837912.

Lovren F, Pan Y, Quan A, Szmitko PE, Singh KK, Shukla PC, Gupta M, Chan L, Al-Omran M, Teoh H, Verma S. Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H656-63. PMID: 20622108.

Verma S, Mesana TG. Mitral-valve repair for mitral-valve prolapse. N Engl J Med. 2009 Dec 3;361(23):2261-9. PMID: 19955526.

Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M, Verma S. Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis. Am J Physiol Endocrinol Metab. 2009 Jun;296(6):E1440-9. PMID: 19351806.

Teoh H, Quan A, Bang KW, Wang G, Lovren F, Vu V, Haitsma JJ, Szmitko PE, Al-Omran M, Wang CH, Gupta M, Peterson MD, Zhang H, Chan L, Freedman J, Sweeney G, Verma S. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab. 2008 Sep;295(3):E658-64.PMID: 18628355.

Wang CH, Anderson N, Li SH, Szmitko PE, Cherng WJ, Fedak PW, Fazel S, Li RK, Yau TM, Weisel RD, Stanford WL, Verma S. Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate. Circ Res. 2006 Sep 15;99(6):617-25. PMID: 16931795.

Verma S, Kuliszewski MA, Li SH, Szmitko PE, Zucco L, Wang CH, Badiwala MV, Mickle DA, Weisel RD, Fedak PW, Stewart DJ, Kutryk MJ. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation. 2004 May 4;109(17):2058-67. PMID: 15078802.

Wang CH, Ciliberti N, Li SH, Szmitko PE, Weisel RD, Fedak PW, Al-Omran M, Cherng WJ, Li RK, Stanford WL, Verma S. Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy. Circulation. 2004 Mar 23;109(11):1392-400. PMID: 14993120.

Verma S, Wang CH, Li SH, Dumont AS, Fedak PW, Badiwala MV, Dhillon B, Weisel RD, Li RK, Mickle DA, Stewart DJ. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation. 2002 Aug 20;106(8): 913-9. PMID: 12186793.
 

Contact:

Division of Cardiac Surgery 
St Michael’s Hospital 
30 Bond Street 
8th Floor, Bond Wing 
Toronto, Ontario 
M5B 1W8 
Telephone 416-864-5997 
Fax 416-864-5881 
Email: vermasu@smh.ca 

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