Faculty: Paul C. Boutros, PhD

Paul C. Boutros, PhDPaul C. Boutros, PhD
Assistant Professor
Department of Medical Biophysics
Department of Pharmacology & Toxicology


General Research Areas:  Biochemical & Molecular Pharmacology; Toxicology;
Using –Omic Technologies to Model Toxicology and Cancer

Biological research is being revolutionized by an influx of high-throughput techniques that generate data in quantities far larger than possible just a decade ago. My lab focuses on using these new types of information to construct accurate models of biology. In particular we focus on understanding how drugs and toxins can induce adverse affects, and in predicting how cancer treatment can be personalized to specific individuals and their unique diseases. Students in my lab come from a broad range of research backgrounds, including biochemistry, mathematics, biology, and computer science. We work close with our clinical colleagues to ensure that our models address the most pressing translational questions regarding treatment targets, toxicity, pharmacology, and efficacy.

Selected Publications:

Boutros PC*, Fraser M+, Harding NJ+, de Borja R+, Trudel D+, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, Zia A, Fox NS, Livingstone J, Shiah YJ, Wang J, Beck TA, Have CL, Chong T, Sam M, Johns J, Timms L, Buchner N, Wong A, Watson JD, Simmons TT, P’ng C, Zafarana G, Nguyen F, Luo X, Chu KC, Prokopec SD, Sykes J, Dal Pra A, Berlin A, Brown A, Chan-Seng-Yue MA, Yousif F, Denroche RE, Chong LC, Chen GM, Jung E, Fung C, Starmans MH, Chen H, Govind SK, Hawley J, D’Costa A, Pintilie M, Waggott D, Hach F, Lambin P, Muthuswamy LB, Cooper C, Eeles R, Neal D, Tetu B, Sahinalp C, Stein LD, Fleshner N, Shah SP, Collins CC, Hudson TJ, McPherson JD, van der Kwast T, Bristow RG* (2015) “Spatial genomic heterogeneity within localized, multi-focal prostate cancer” Nature Genetics (in press) (PMID: 26005866)

Ewing AD*, Houlahan KE*, Hu Y*, Ellrott K, Caloian C, Yamaguchi TN, Bare JC, P’ng C, Waggott D, Sabelnykova VY, ICGC-TCGA DREAM Somatic Mutation Calling Challenge Participants, Kellen MR, Norman TC, Haussler D, Friend SH, Stolovitzky G, Margolin A, Stuart JM, Boutros PC (2015) “Combining accurate tumour genome simulation with crowd-sourcing to benchmark somatic single nucleotide variant detection” Nature Methods (in press) (PMID: 25984700)

Anghel CV, Quon G, Haider S, Nguyen F, Deshwar AG, Morris QD*, Boutros PC* (2015) “ISOpureR: an R implementation of a computational purification algorithm of mixed tumour profiles” BMC Bioinformatics 16:156 (PMID: 25972088)

Starmans MH, Pintilie M, Chan-Seng-Yue M, Moon NC, Haider S, Nguyen F, Lau SK, Liu N, Kasprzyk A, Wouters BG, Der SD, Shepherd FA, Jurisica I, Penn LZ, Tsao MS, Lambin P, Boutros PC (2015) “Integrating RAS status into prognostic signatures for adenocarcinomas of the lung” Clinical Cancer Research 21(6):1477-1486 (PMID: 25609067)

Lalonde E*, Ishkanian AS*, Sykes J, Fraser M, Ross-Adams H, Erho N, Dunning MJ, Lamb AD, Moon NC, Zafarana G, Warren AY, Meng X, Thoms J, Grzadkowski MR, Berlin A, Have CL, Ramnarine VR, Yao CQ, Malloff CA, Lam LL, Xie H, Harding NJ, Mak DY, Chu KC, Chong LC, Sendorek DH, P’ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC*, Bristow RG* (2014) “Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study” Lancet Oncology 15(13):1521-1532 (PMID: 25456371)

Ontario Institute for Cancer Research
MaRS Centre
661 University Avenue, Suite 510
Toronto, Ontario, Canada, M5G 0A3
Tel: 416-673-8564
Fax: 416-673-8564
Email: paul.boutros@oicr.on.ca
Web: http://labs.oicr.on.ca/boutros-lab