Graduate Courses

 

COURSE DESCRIPTION, PRE-REQUISITES/CO-REQUISITES COORDINATOR

PCL1001Y (Y)

Fall                         M, 2:00-4:00pm;
W, 11:00am-1:00pm   MSB2172

Winter                  M, 2:00-4:00pm;
W, 10:00am-12:00pm
MSB2172

Systems Pharmacology

This is a comprehensive pharmacology course covering concepts of drug properties and interactions with living systems. Students will attend lectures examining mechanisms of action, clinical use, and adverse effects of drugs acting on the nervous (autonomic and central), cardiovascular, renal, respiratory, gastrointestinal, immunological and endocrine systems. Endogenous compounds, antimicrobial drugs, anti-inflammatory drugs, chemotherapy, and other special topics will also be discussed. Critical evaluation of primary literature and examination of clinical problem-based case studies will be integrated with lecture material through writing assignments and small group sessions.

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Students would be expected to have a general background in biology, biochemistry, pharmacology and/or physiology. Priority will be given to students enrolled in the Applied Clinical Pharmacology field of study. Non-Pharmacology graduate students may request this course via an Add/Drop Course form. A complete transcript must accompany the form.
Dr. Michelle Arnot

PCL1002Y (Y)

Fridays,10:00am MSB4227

Graduate Pharmacology

A series of lectures and student presentations that emphasize recent advances in our understanding of pharmacological principles. Areas covered include drug metabolism, molecular biology, pharmacogenomics, receptors & signal transduction, clinical pharmacology, and behavioural pharmacology. Each student presents a critical evaluation of a recent research paper during the year. Testing will be in-class exam format and completion of a CIHR-style operating grant application.

Dr. D. Riddick

PCL1003Y (Y)

Seminars in Pharmacology

Open to Pharmacology PhD students only. Enrolment in this course is automatic for all Pharmacology PhD students. This is the Thursday afternoon (4:00 pm) Departmental Seminar Series. Seminars are given by invited external speakers, Department faculty members and doctoral students prior to the completion of their program. Students remain registered in this course until completion of the PhD program, at which time they are assigned credit for the course. Attendance is monitored by a sign-up sheet. Although students are not expected to attend every seminar, a minimum attendance level of 50 seminars is required (or 50% of seminars offered, whichever is less), to receive course credit, and students will be penalized for a poor attendance record. The penalty will be essay assignment(s) on seminar topics that the student has missed.

Additional requirements for this course are the presentation of two Departmental seminars during the course of the PhD program:

  • One 30-min seminar (20 min talk, 10 min question period) giving a summary of work in progress or of particular projects or sets of experiments that have been completed. (Will be scheduled around the 3rd-year of enrolment).
  • One 60-min seminar (40 min talk, 20 min question period) giving an overview of all of the results of the thesis research, which is usually given between 2 and 6 months prior to the Departmental thesis defense.

No formal grade is assigned to PCL1003Y. It is a Credit/Non-Credit course.

Dr. A. Salahpour

​PCL1004Y (Y)

Clinical Pharmacology

This course aims at familiarizing the student with the rapidly growing field of clinical pharmacology. Graduates may pursue a career in this field in a hospital setting, in the pharmaceutical industry or regulatory agencies. The first part of the course focuses on clinical pharmacokinetics. The second part is devoted to selected topics in clinical pharmacology with special emphasis on how to design and interpret drug studies.

Dr. C. Woodland

JPM1005Y (Y)

To be offered 20179.

Behavioral Pharmacology

The goal of this course is to examine the methodologic and experimental basis of studying the effects of drugs on behaviour. Throughout the course the relationship of pre-clinical behavioural pharmacology to human behavioural pharmacology is compared. There will be a strong emphasis on how behavioural studies can assist in our understanding of the underlying mechanisms and identification of novel therapeutic approaches for various mental illnesses and addictions. In the first part of the course, general background covering the principles of behavioural pharmacology will be covered. This approach ensures that students somewhat weaker in relevant areas of psychology or pharmacology are able to gain such knowledge early in the course. In the second part of the course, there is a focus on selected topics and current experimental issues in the field including several chosen by the class. Instruction will include a 45 minute overview of the topic given by the lecturer followed by a discussion of two research papers provided one week in advance. Structured questions are provided to guide preparation and discussion. An opportunity to observe/participate in some of the behavioural techniques described in the class will be offered.

(Offered in alternate years; Minimum enrolment of 4 students)

Dr. L. Zawertailo

JPY1007Y (Y)

Neuropharmacology of Neurotransmitter Receptors

In this course, we consider basic questions of mechanism and structure as they relate to neuroreceptors and receptor-mediated signalling. The focus is primarily at the molecular level, with an emphasis on principles and concepts that are relevant to receptors of all classes. Specific examples are drawn largely from the family of G protein-coupled receptors (GPCRs) and, to a lesser extent, from the family of ligand-gated intrinsic ion channels.

The early lectures deal primarily with basic pharmacological concepts (e.g., potency, affinity, efficacy), the acquisition and presentation of data in systems under thermodynamic (i.e., equilibrium) and kinetic control, and the interpretation of data in terms of widely used models that purport to offer a physically realistic description of the system (e.g., distinct non-interconverting sites, mobile or ‘floating' receptors, co-operativity among interacting sites). The balance of the course deals primarily with structure, the relationship between structure and function, and the interactions among receptors and attendant proteins in the signalling pathway. Included is a consideration of various pharmacological, biochemical and molecular genetic approaches to the understanding of receptors and their dysfunction. The course ends with a discussion of neuroimaging, particularly positron emission tomography, and its application in vivo, both in health and in disease.

The grade will be based on the answers to a series of problem sets that are assigned and graded by individual lecturers over the course of the lectures. See Lecture Schedule. [The order of the lectures is subject to change, and a final schedule will be made available when the course begins in September].

(Offered in alternate years; Minimum enrolment of 8 students)

  • Prerequisites: It is expected that students will have a first degree in one of the biological sciences or in a physical science, such as chemistry, with some biological component. In past years, members of the class have come from a broad range of academic backgrounds. Topics therefore are presented in a manner that recognises this diversity.
Dr J. Wells

PCL1012H (Y)

Cognitive Neuropharmacology

This course is intended to provide a critical overview of the drug research and development process as applied to the evaluation of pharmacological agents for the treatment of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. The first part of the course will first cover the theory underlying treatment of the disorders at both symptomatic and disease modifying levels and will review the drug research and development process as applied to these diseases. The topics covered will include: (a) identifying the key features of the disorder; (b) the use of animal models in preclinical evaluation; (e) translational modeling; and (f) clinical evaluation. The second part of the course will deal with specific pharmaceuticals that are either approved or currently under development for the treatment of these neurodegenerative disorders.

The course will meet on 14 occasions over the year (7 meetings during the first semester and 7 during the second). Each class will be three hours in length. In the first part of the course the students will be responsible for knowing material covered in lectures and assigned readings. There will also be time allotted for classroom discussions. The last part of the course will use a seminar format with student presentations.

(Offered alternate years over the course of the year; Minimum enrolment of 4, maximum of 15)

  • Prerequisites: To qualify, students must have either at least 1 year of neuroscience courses or a fourth year course in pharmacology.
  • Enrolment must be completed by the first week of September.
Dr. N.W. Milgram and Dr. Guy Higgins

JNP1014Y (Y)

Tuesdays, 10:00am-12:00pm, MSB2172

Interdisciplinary Toxicology

A survey course examining several contemporary topics in toxicology with emphasis on human/mammalian toxicology. Topics in the course may include: adverse drug reactions, acute poisonings, natural toxins, maternal-fetal toxicology, forensic toxicology, environmental chemistry, pesticides, dioxins, endocrine disruptors, regulatory toxicology, occupational toxicology, food toxicology, herbal products, alcohol, smoking, and drugs of abuse. Students are evaluated by their performance on written tests and assignments.

  • Recommended Preparation: BCH210H, PCL201H,  PCL302H, PCL362H, or their equivalents.
Dr. C. Woodland and Dr. J.Peter McPherson

JNP1016H (S)

To be offered 20171.      Thursdays 10:00am-12:00pm

 

Graduate Seminar in Toxicology

This course is a seminar-based course in which students critique scientific papers in the area of toxicology. Faculty members from a wide variety of disciplines will guide these sessions and give an overview of the relevant issues in the field. Students are evaluated by oral and written critiques of the scientific literature and by their participation in class discussions. This is a compulsory course for all MSc and PhD students in the Collaborative Program in Biomedical Toxicology. It is also open to other qualified graduate students if space permits.

(Offered alternate years)

Dr. A. Salahpour

JNP1017H (S)

To be offered 20171.

Current Topics in Molecular and Biochemical Toxicology

This course will emphasize the biochemical principles and mechanisms underlying the toxicity of drugs and foreign agents. In particular the current hypotheses that explain the events at the molecular level which determine and affect toxicity are examined and critically evaluated. This course is suitable for graduate students of pharmacy, toxicology, pharmacology, biochemistry, environmental science, pathology, neuroscience and medical biophysics. A weekly journal club will also be held after the lectures.

(Offered in the spring, alternate years)

  • Permission of the Pharmaceutical Sciences Department is required.
Dr. J. Henderson

JNP1018H (S)

Molecular and Biochemical basis of Toxicology I

This course will emphasize the molecular biology principles and mechanisms underlying the toxicity of drugs and foreign agents. A journal club format is used to examine and critically evaluate the current hypotheses that explain the events at the molecular level which determine and affect toxicity. This course is suitable for graduate students of pharmacy, toxicology, pharmacology, biochemistry, environmental science, pathology, neuroscience and medical biophysics. A weekly journal club will also be held after the lectures.

(Offered in the spring, alternate years)

  • Permission of the Pharmaceutical Sciences Department is required.
  • JNP1017H is not a prerequisite for this course.
Dr. J. Henderson and Dr. P.J. O'Brien

PCL1100H (Summer)

Applied Skills in Clinical Pharmacology

This course introduces fundamental principles of clinical research and provides students with the skills necessary for the design, execution, analysis, and critical evaluation of clinical studies in pharmacology. Students will become familiar with various research approaches, methodologies, and strategies commonly employed in clinical pharmacology. Specifically, lectures will cover observational and experimental study designs and techniques; clinical data measurements, collection, and analysis; evidence review (systematic reviews/meta-analysis); ethical, legal, and regulatory guidelines governing clinical research; safety monitoring and adverse event reporting (pharmacovigilance); and key principles of pharmacoeconomics. In addition, students will be introduced to current topics and conceptual issues related to clinical research in pharmacology, and will learn to critically appraise clinical research.

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Students enrolled in the Applied Clinical Pharmacology field of study only.
Dr. Nicole Mittmann

PCL1101H (Summer)

Technology, Techniques and Translation in Pharmacology & Toxicology

This series of interactive seminars and workgroups will explore methodologies relevant to the translation of molecular discoveries into clinical studies, and vice versa, through examples in select disease areas. We will examine techniques and technologies for in vitro, in vivo and ex vivo modeling of disease, drug action, and drug disposition. Methodologies enabling the measurement of surrogate outcomes including biomarkers from blood samples and clinical imaging modalities will be explored. Students will learn how clinical trials and alternative sources of data including consortia databases and public health records can be used to evaluate the benefits and adverse consequences of pharmacological treatment. Both commonly applied statistical methods and novel/alternative approaches to data analysis will also be considered.

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Students enrolled in the Applied Clinical Pharmacology field of study only.
Dr. Walter Swardfager

JFK1120H (F)

Selected Topics in Drug Development I

This course is designed to introduce graduate students to general research and drug development in the pharmaceutical industry. Lectures will focus on government regulations, phase I through phase IV studies, marketing and quality control requirements in new drug approval. The course format is a combination of lectures given by faculty, specialist in the pharmaceutical industry and workshops.

(Maximum enrolment 15, not currently offered)

  • This course must be requested through ROSI.
  • Permission of the Pharmaceutical Sciences Department is required.
Dr. M. Piquette-Miller and Dr. C. Allen

JFK1121H (S)

Selected Topics in Drug Development II

This course provides an in-depth examination of several issues facing the pharmaceutical scientists. Students will be required to apply fundamental principles of pharmaceutics and pharmacokinetics to current problems that are being faced in the pharmaceutical industry. Contemporary issues in pharmaceutics and pharmacokinetics will be covered. The course format is a combination of lectures given by faculty, specialist in the pharmaceutical industry and workshops.

(Offered in the spring, alternate years)

  • Prerequisite: JFK1120H.
  • Permission of the Pharmaceutical Sciences Department is required.
Dr. S.Wu and Dr. P. Lee

JFK1122H (F)

Drug Transport Across Biological Membranes

The course is to provide graduate students with a knowledge of the molecular entities involved in drug transport across biological cell membranes and to emphasize the physiological and clinical significance of these entities. The course will consist of didactic lectures presented in a traditional lecture format, and student presentations, when appropriate a lecture will be replaced by a research seminar.

(Offered in the fall, alternate years; Maximum enrolment of 10)

  • Permission of the Pharmaceutical Sciences Department is required.
Dr. R. Bendayan

PCL1402H (F)

Tuesdays 3:00-6:00pm MSB2172

Pharmacology & Toxicology in Drug Development

The aim of this course is to provide instruction on the basic principles of drug development, with a primary focus on the application of fundamental principles of pharmacology and toxicology to the design and conduct of early phase clinical trials. Students will become familiar with the standard safety and pharmacokinetic assessments that take place during early clinical development, as well as with proof-of-concept and proof-of-mechanism studies, evaluations of exposure- toxicity relationships and refinement of dose selection for later phase trials. In addition to actual clinical studies, the course will examine various modeling approaches that are also conducted during drug development. At the end of the course, students should understand the phases of drug development, be able to design an early phase clinical study, understand the standardized practices and ethical implications of clinical research, and be aware of some of the scientific and non-scientific career paths/roles in drug development.

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Students would be expected to have a general background in biology, biochemistry, pharmacology and/or physiology. Priority will be given to students enrolled in the Applied Clinical Pharmacology field of study. Non-Pharmacology graduate students may request this course via a Add/Drop Course form. A complete transcript must accompany the form.
Dr. R. Laposa

JNR1444Y (Y)*

Fundamentals of Neurological Science

The purpose of this course is to give undergraduate students an overview and grounding in the fundamentals of neuroscience. The main emphasis is on the cellular and molecular aspects of brain function. The lecturers, all experts in their respective topics, are drawn from the different university departments and associated research institutes. Each year the course is updated to reflect the rapid evolution of ideas in neuroscience.

This course is open to both graduate and senior undergraduate students, however, it is a rigorous course that has been primarily designed for graduate students. To facilitate extensive student-instructor interaction, enrollment will be capped. Permission of the Physiology Department is required.

  • *This course is also offered as two half-year courses worth a half credit each.  See PSL1445H and PSL1446H.

Dr. James Eubanks

416-603-5800 Ext 2933 or Ext 2469

PCL1491H (S)

Fridays, 1:00pm-5:00pm

Clinical Pharmacology: Principles in Practice

The overall goal of this laboratory course is to provide students with practical experience and understanding of experimental methods used in clinical pharmacology research. The 12-session course will be taught through a combination of wet labs and dry labs. During wet labs, groups (~3-5 individuals per group) will be given a drug that they will investigate in the laboratory. Dry labs will involve lectures, case studies, and assignments. Topics will include assessments of drug solubility, absorption/bioavailability and bioequivalence, distribution and protein binding, biotransformation, renal excretion, pharmacokinetic and pharmacodynamics modeling, drug-drug interaction, and assessment of pharmacodynamic effects.

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Students would be expected to have a general background in biology, biochemistry, pharmacology and/or physiology. Priority will be given to students enrolled in the Applied Clinical Pharmacology field of study. Non-Pharmacology graduate students may request this course via a Add/Drop Course form. A complete transcript must accompany the form.
Dr. A. Hamadanizadeh

JYG1555H (S)

Topics in Molecular and Cellular Neurobiology

This course focuses upon selected topics in molecular genetics and cellular neurobiology. Students will be expected to make presentations based upon appropriate recent literature. Participation in discussions will also be required. There will be no didactic lectures. Presentation topics will be chosen from four broad areas of neurobiology; signaling in cells of the nervous system, development of cells of the nervous system, plasticity of the nervous system and molecular genetics of neural diseases.

(Offered in the spring, alternate years; Minimum enrolment of 15) - Status TBA

  • The course cannot be requested through ROSI
  • Permission of the Physiology Department is required.
Dr. L-Y Wang

PCL2200Y (Y)

Major Research Project

The aim of this course is to give students an opportunity to conduct independent research in pharmacology. Students will be matched to faculty members who will supervise their project and provide guidance and assistance. Students will be required to apply their knowledge of pharmacology and research methodologies. This course will allow students to acquire important practical skills, in-depth knowledge of the research subject, and develop scientific communication skills.

(Continuing Course)

  • Prerequisites/Co-requisites/Exclusions/Enrolment Restrictions: Enrolment in this course is automatic for all students enrolled in the Applied Clinical Pharmacology field in the Department of Pharmacology & Toxicology. Pre-requisite or Co-requisite: PCL1100H.
Dr. C. Woodland

 

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