L. Trevor Young

As an active clinician scientist, Dr. Young’s principal research interest includes understanding the molecular basis of mood disorders and their treatment and how to apply these findings to the clinical setting. His research is particularly focused on understanding the processes that lead to long-term changes in brain structure and function in patients with bipolar disorder and how these changes can be targeted by mood stabilizing drugs.
 

Selected Publications:

Andreazza AC, Shao L, Wang JF, Young LT. Decreased mitochondrial complex I activity and increased oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatry. 2010; 67(4):360-8.

Johnson SA, Wang JF, Sun X, McEwen BS, Chattarji S, Young LT. Lithium treatment prevents stress-induced dendritic remodeling in the rodent amygdala. Neuroscience. 2009; 163(1):34-9

Shao L, Cui J, Young LT, Wang JF. The effect of mood stabilizer lithium on expression and activity of glutathione s-transferase isoenzymes. Neuroscience. 2008; 151(2):518-24.

Wood GE, Young LT, Reagan L, Chen B, McEwen B. Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment. Proc Natl Acad Sci USA. 2004;101(11):3973-8.

Xiujun Sun, L. Trevor Young, Jun-Feng Wang, Paul Grof , Gustavo Turecki , Guy A. Rouleau, Martin Alda: Identification of Lithium Regulated Genes in Cultured Lymphoblasts of Lithium Responsive Subjects with Bipolar Disorder. Neuropsychopharmacology 2004; 29(4):799-804.

Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol. Psychiatry. 2001; 50(4):260-5.

Young LT, Joffe RT, Robb JC, MacQueen GM, Marriott M, Patelis Siotis I. Double-blind comparison of addition of a second mood stabilizer versus an antidepressant to an initial mood stabilizer for treatment of patients with bipolar disorder. Am J Psychiatry. 2000; 157:124-126.

Dowlatshati D, MacQueen GM, Wang JF, Young LT. Increased temporal cortex CREB levels are increased by antidepressant treatment in major depression. Lancet. 1998; 352: 1754-1755.