Temerty Faculty of Medicine
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Health and Wellness
Professor

David S. Riddick

Pharmacology and Toxicology

PhD

David S. Riddick

david.riddick@utoronto.ca

Publications

Location
Medical Sciences Building
Address
1 King's College Circle, Room 4204, Toronto, Ontario Canada M5S 1A8
Research Interests
drug safety, toxicology
Appointment Status
Primary
Accepting
Not accepting graduate students

For nearly 30 years, my research laboratory studied the regulation of cytochromes P450 and other drug-metabolizing enzymes by environmental pollutants, therapeutic agents, and hormones. Since closing the lab, I continue to work on scholarly writing and editorial projects related to these topics.

Selected Publications

  1. Riddick DS. Canadian content in the pages of Drug Metabolism and Disposition: a comprehensive historical analysis. Drug Metab. Dispos. 2024; 52: 1-18.
  2. Riddick DS. Fifty years of aryl hydrocarbon receptor research as reflected in the pages of Drug Metabolism and Disposition. Drug Metab. Dispos. 2023; 51: 657-671.
  3. Riddick DS. Pharmacokinetics: Overview. In "Comprehensive Pharmacology”, 1st Edition. (T.P. Kenakin, editor-in-chief) Elsevier, Amsterdam. 2022; 403-405.
  4. Riddick DS and Mullen Grey AK. Mechanisms of NADPH-cytochrome P450 oxidoreductase induction by dexamethasone in the H4IIE rat hepatoma cell line. Can. J. Physiol. Pharmacol. 2020; 98: 267-274.
  5. Crosby M and Riddick DS. Suppression of hepatic CYP3A4 expression and activity by 3-methylcholanthrene in humanized PXR-CAR-CYP3A4/3A7 mice. Drug Metab. Dispos. 2019; 47: 279-282.
  6. Utgikar R and Riddick DS. Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines. Can. J. Physiol. Pharmacol. 2017; 95: 768-771.
  7. Hunter SR, Vonk A, Mullen Grey AK and Riddick DS. Role of glucocorticoid receptor and pregnane X receptor in dexamethasone induction of rat hepatic aryl hydrocarbon receptor nuclear translocator and NADPH-cytochrome P450 oxidoreductase. Drug Metab. Dispos. 2017; 45: 118-129.
  8. Lee C, Mullen Grey AK, and Riddick DS. Loss of aryl hydrocarbon receptor protein in adrenalectomized rats does not involve altered levels of the receptor's cytoplasmic chaperones. Can. J. Physiol. Pharmacol. 2013; 91: 1154-1157.
  9. Lee C, Ding X, and Riddick DS. Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. Drug Metab. Dispos. 2013; 41: 1782-1786. 
  10. Lee C, Ding X, and Riddick DS. The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene. Drug Metab. Dispos. 2013; 41: 457-465.
  11. Wu AML, Dalvi P, Lu X, Yang M, Riddick DS, Matthews J, Clevenger CV, Ross DD, Harper PA, and Ito S. Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol. Pharmacol. 2013; 83: 377-388.
  12. Riddick DS, Ding X, Wolf CR, Porter TD, Pandey AV, Zhang QY, Gu J, Finn RD, Ronseaux S, McLaughlin LA, Henderson CJ, Zou L, and Flück CE. NADPH-Cytochrome P450 reductase: roles in physiology, pharmacology, and toxicology. Drug Metab. Dispos. 2013; 41: 12-23.